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Organic calcium and magnesium citrate minerals plus vitamins D and K
Cal Mag Vanilla Liquid + helps to maintain bone health and muscle function using a combination of organic calcium and magnesium citrate minerals, plus vitamins D and K. Osteoporosis is the primary cause of bone fractures in postmenopausal women 50 years and older, with an estimated 80% of all fractures in this group being osteoporosis related.1 Regular physical activity helps to maintain bone mass during aging, as bone metabolism is stimulated by the mechanical stress generated from impacts.2-5 However, supplementation with calcium and vitamin D may support bone formation even when incorporated into a low-impact physical exercise program. In a randomized clinical trial, 64 healthy postmenopausal women received 500 mg of calcium and 1000 IU of vitamin D daily while undergoing 6 months of low-impact aquatic exercise. At the end of the study period, there was a 15.8% increase in bone formation biomarker P1NP (precollagen type 1 amino-terminal propeptide) compared to baseline measurements.6 P1NP has been identified as a clinically relevant osteoporosis risk biomarker by the Bone Marker Standards Working Group.7 Vitamin K helps to maintain bone health, partly via the activation of gamma-carboxyglutamic acid (GLA) proteins involved in skeletal mineralization, such as matrix Gla protein (MGP) and osteocalcin.8,9 Low vitamin K status may impair the function of Gla proteins involved in regulation of bone mineralization.10
REFERENCES
1. Bessette L, Ste-Marie LG, Jean S, Davison KS, Beaulieu M, Baranci M, Bessant J, Brown JP. Osteoporos Int. 2008; 19: 79-86
2. Yamazaki S, Ichimura S, Iwamoto J, Takeda T, Toyama Y. J Bone Miner Metab. 2004; 22: 500-508
3. Chien MY, Wu YT, Hsu AT, Yang RS, Lai JS. Calcif Tissue Int. 2000; 67: 443-448
4. Bemben DA, Bemben MG. Osteoporos Int. 2011; 22: 179-186
5. Vainionpää A, Korpelainen R, Leppäluoto J, Jämsä T. Osteoporos Int. 2005; 16: 191-198
6. Moreira LDF, Fronza FCAO, dos Santos RN, Zach PL, Kunii IS, Hayashi LF et al. J Bone Miner Metab. 2014; 32: 411-419
7. Wheater G, Elshahaly M, Tuck SP, Datta H, Van Laar JM. Journal of Translational Medicine. 2013, 11: 201
8. Price P. Connect Tissue Res. 1989; 21:51-57
9. Loeser R, Varnum B, Carlson C, et al. Arthritis Rheum. 1997; 40:1455-1465
10. Misra D, Booth SL, Tolstykh I, Felson DT, Nevitt MC, Lewis CE et al. Am J Med. 2013; 126(3): 243-248
EACH TABLESPOON (15 mL) CONTAINS: Vitamin D (cholecalciferol) . . . .. . . . . . . . . . . . . . . .25 mcg (1000 IU) Vitamin K1 (phylloquinone) . . . . . . . . . . . . . . . . . . . .40 mcg Vitamin K2 (menaquinone-7) . . . . . . . . . . . . . . . . . . .60 mcg Calcium (calcium citrate) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .500 mg Magnesium (magnesium citrate) . . . . . . . . . . . . . . . . . . . . . . .200 mg
Non-Medicinal Ingredients: Purified water, xylitol, natural vanilla flavour, medium-chain triglycerides, citric acid, xanthan gum, potassium sorbate, organic stevia leaf extract, rosemary leaf extract, mixed tocopherols concentrate
Recommended Adult Dose: Take 1 tablespoon daily with a meal, a few hours before or after taking other medications or natural health products, or as recommended by your healthcare practitioner. Shake well before each use. Do not drink directly from the bottle.
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Our probiotics are stored in our warehouse under refrigeration to guarantee quality and maintain optimal potency. Additionally, we include a FREE ice pack with probiotic shipments. Although the product may not arrive cold, the ice pack helps in preserving a cooler temperature during transit. We recommend taking into account potential weekend or holiday delays when placing your order. For example, it's best to order on a weekday and avoid ordering on Fridays, Saturdays, or during holidays
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