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Understanding Drug Interactions and Vitamin Depletion

by Nature's Source 26 Feb 2025
Understanding Drug Interactions and Vitamin Depletion

Introduction

In today’s health-conscious world, understanding the interactions between drugs and vitamins is critical for maintaining optimal health. This guide explores the prevalence of Natural Health Products (NHPs), their interactions with pharmaceuticals, and how to navigate these complexities to support your wellness journey. Our passion for people, health, and well-being drives us to uphold the highest standards in clean formulations, evidence-based medicine, and personalized nutritional support.

 Why a Drug Interaction Guide?

Summary of Current State of NHP and Rx Usage in Canadian Households

  1. Upwards of 71% of Canadians use Natural Health Products (NHPs).

  2. Canadians widely use NHPs alongside pharmaceutical medications.

  3. Consumer knowledge and confidence about NHPs continues to increase.

  4. Reliable data collection on NHP usage combined with Rx usage is weak if not non-existent.

Who Buys and Uses NHPs, and How Much?

The Gold Standard survey, prepared for Health Canada by Ipsos Reid in 2011, provides insights into NHP usage:

Older age groups were associated with increased NHP use (1.5x increase per age decile). Pharmacists documented NHP use in 41% of patients, compared to 22% by physicians and 19% by nurses. The studies show that concurrent use of NHPs with drugs is very high, and consumers often persist in their use despite professional recommendations.

Trends in Drug Use 

Below is Health Canada’s data on drug sales growth:

  • Canada accounts for 2.1% of pharmaceutical drug sales worldwide.

  • Patented medicine sales reached $17.5 billion in 2020, with a 3% growth over the past five years.

(Source: PMPRB Annual Report, 2020)

The Current State of NHP and Pharmaceutical Use in Canada

  • NHP Usage: Over 71% of Canadians use NHPs. These products, including vitamins, minerals, and herbal remedies, are often used alongside pharmaceutical medications.

  • Consumer Trends: While confidence in NHPs is increasing, reliable data on their combined usage with pharmaceuticals is limited.

  • Demographics: Older Canadians are more likely to use NHPs, and women use nutritional supplements more frequently than men, particularly in the 51-70 age group. Western Canada sees higher NHP usage compared to the East.

Key Findings

  • Most Common NHPs: Multivitamins remain the most widely used, though their usage has declined slightly over the years. Vitamin D usage has significantly increased, especially among those aged 70 and older.

  • Trends in Pharmaceuticals: Canada accounts for 2.1% of global pharmaceutical sales, with patented medicine sales reaching $17.5 billion in 2020. This reflects a steady growth in drug usage.

Chart: Top 10 Drug Classes by Public Drug Program Spending (2019)

Drug Class

TPS ($ Millions)

Proportion of TPS (%)

Common Uses

Tumor Necrosis Factor Alpha Inhibitors (Anti-TNF Drugs)

576.7

7.4

Rheumatoid Arthritis, Crohn’s Disease

Antineovascularization Agents

337.3

4.3

Age-Related Macular Degeneration

HMG-CoA Reductase Inhibitors (Statins)

295.6

3.8

High Cholesterol

Proton Pump Inhibitors (PPIs)

249.6

3.2

Gastroesophageal Reflux Disease

Adrenergics with Corticosteroids

217.3

2.8

Asthma, Chronic Bronchitis

ACE Inhibitors

190.7

2.5

Heart Failure, High Blood Pressure

Selective Serotonin Reuptake Inhibitors (SSRIs)

185.8

2.4

Depression

Natural Opium Alkaloids

180.5

2.3

Pain Management

Other Antidepressants

171.5

2.2

Depression

Diazepines, Oxazepines, Thiazepines

155.9

2.0

Schizophrenia, Bipolar Disorder

Combined Total

2,560.9

32.9


 

Common Drug Classes and Their Interactions

Acid Inhibitors and Antibiotics 

Drug Class

Examples

Nutrients Depleted

Interactions

Acid Inhibitors

Omeprazole, Lansoprazole

Calcium, Magnesium, Vitamin B12

Long-term use may lead to nutrient depletion; separate calcium and magnesium supplementation.

Antibiotics

Amoxicillin, Ciprofloxacin, Tetracyclines

Vitamin K, B-Vitamins, Probiotics

Antibiotics disrupt gut flora; probiotics should be taken 4-6 hours after to restore balance.

H2 Antagonists

Ranitidine, Cimetidine

Zinc, Calcium

Decreased absorption of zinc and calcium; supplementation should be spaced.

Anticonvulsants 

Drug Class

Examples

Nutrients Depleted

Interactions

Anticonvulsants

Phenytoin, Carbamazepine

Vitamin D, Calcium, Folate, B12

Grapefruit juice may increase drug levels; folate supplementation may reduce drug efficacy.

Valproic Acid

Depakote

Carnitine, Selenium

High doses of vitamin A may increase the risk of birth defects in pregnant women.

Benzodiazepines

Lorazepam, Diazepam

Coenzyme Q10, Riboflavin

Avoid sedating herbs like Kava or Valerian; these may cause excessive drowsiness.

Cardiovascular Medications 

Drug Class

Examples

Nutrients Depleted

Interactions

ACE Inhibitors

Captopril, Enalapril, Ramipril

Zinc Glycinate

Should not be combined with potassium; may cause hyperkalemia.

Beta Blockers

Atenolol, Metoprolol

Coenzyme Q10

Calcium supplements may lower drug levels, decreasing efficacy.

Calcium Channel Blockers

Nifedipine, Verapamil

None Known

Avoid peppermint oil, which may reduce the drug’s effectiveness.

Cardiac Glycosides

Digoxin

Calcium Citrate, Magnesium

St. John’s Wort may reduce drug efficacy, and magnesium may decrease absorption; take 2 hrs apart.

 

Simple Supplement Tips

1.      Take Vitamin C to enhance iron absorption.

2.      Space probiotics and antibiotics by 4-6 hours for efficacy.

3.      Avoid taking fatty acids with fatty meals to optimize absorption.

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